List of Validated Methods
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No.AnalyteMethodLLOQ (ng/mL)Note
1 11-Deoxycortisol HPLC/MS/MS 0,02 determination of endogenous levels in postmenopausal women
2 17-Carboxybudesonide HPLC/MS/MS 0,1 in dog plasma
3 17-Deacetylnorgestimate HPLC/MS/MS 0,02  
4 17-Hydroxyprogesterone HPLC/MS/MS 0,02 determination of endogenous levels in postmenopausal women
5 1-Adamantylethyloxy-3-morpholino-2-propanol HPLC/MS/MS 0,05  
6 2-Hydroxymethylmetronidazole HPLC/MS/MS 4  
7 5'-Deoxy-5-fluorocytidine HPLC/MS/MS 25  
8 5'-Deoxy-5-fluorouridine HPLC/MS/MS 25  
9 5-Fluorouracil HPLC/MS/MS 5  
10 5-Hydroxymethyltolterodine HPLC/MS/MS 0,05  
11 5-Hydroxypropafenone HPLC/MS/MS 0,5  
12 9-Hydroxyrisperidone HPLC/MS/MS 0,1  
13 Abiraterone HPLC/MS/MS 0,2  
14 Acetaminophen (paracetamol) HPLC/MS/MS 250  
15 Acetazolamide HPLC/MS/MS 250  
16 Acetylcysteine HPLC/MS/MS 50  
17 Acetylsalicylic acid HPLC/MS/MS 25 common method with salicylic acid
18 Acetylsalicylic acid HPLC/MS/MS 5 common method with salicylic acid
19 Aciclovir HPLC 15  
20 Aciclovir HPLC/MS/MS 5  
21 Agomelatine HPLC/MS/MS 0,1  
22 Aldosterone HPLC/MS/MS 0,01 determination of endogenous levels in postmenopausal women
23 Alendronate HPLC/MS/MS 0,75  
24 Amlodipine HPLC/MS/MS 0,1  
25 Amlodipine HPLC/MS/MS 0,5 rat plasma direct injection
26 Amlodipine chiral HPLC/MS/MS 0,2  
27 Amoxicillin HPLC/MS/MS 100  
28 Anagrelide HPLC/MS/MS 0,075  
29 Anastrozole HPLC/MS/MS 0,5  
30 Androstenedione HPLC/MS/MS 0,02 determination of endogenous levels in postmenopausal women
31 Aripiprazene HPLC/MS/MS 0,1  
32 Aripiprazole HPLC/MS/MS 0,4  
33 Atomoxetine HPLC/MS/MS 5  
34 Atorvastatin HPLC/MS/MS 0,8 common method with ezetimibe
35 Atorvastatin HPLC/MS/MS 0,5  
36 Atorvastatin HPLC/MS/MS 0,25 common method with Ezetimibe and Ezetimibe Glucuronide
37 Azithromycin HPLC/MS/MS 4  
38 Bendroflumethiazide HPLC/MS/MS 0,4  
39 Bicalutamide chiral HPLC/MS/MS 1  
40 Bicalutamide HPLC/MS/MS 2  
41 Bisoprolol HPLC/MS/MS 0,5  
42 Bosentan HPLC/MS/MS 5  
43 Budesonide HPLC/MS/MS 0,05 in dog plasma
44 Bumetanide HPLC 4  
45 Caffeine HPLC/MS/MS 100 common method with paraxantine
46 Candesartan HPLC/MS/MS 2  
47 Capecitabine HPLC/MS/MS 100  
48 Captopril (free) HPLC/MS/MS 1  
49 Captopril (free) HPLC 15  
50 Carbamazepine HPLC 25  
51 Carbocisteine HPLC/MS/MS 50  
52 Carvedilol HPLC/MS/MS 1  
53 Carvedilol metabolite M IV HPLC/MS/MS 0,2  
54 Cefditoren HPLC/MS/MS 50  
55 Cefixime HPLC/MS/MS 100  
56 Cefprozil HPLC/MS/MS 100  
57 Cefuroxime HPLC/MS/MS 50  
58 Celecoxib HPLC/MS/MS 10  
59 Chlorambucil HPLC/MS/MS 1  
60 Chlorthalidone HPLC/MS/MS 2  
61 Cilostazol HPLC/MS/MS 50  
62 Ciprofloxacine HPLC/MS/MS 50  
63 Clarithromycin HPLC/MS/MS 50  
64 Clobazam HPLC/MS/MS 1  
65 Clozapin GC/MS 0,6  
66 C-peptide ELISA 0,2  
67 Dapagliflozin HPLC/MS/MS 2 common method with linagliptin
68 Darunavir HPLC/MS/MS 200  
69 Dasatinib HPLC/MS/MS 0,25  
70 Desethyloxybutynin GC/MS 2  
71 Desethyloxybutynin HPLC 4  
72 Desloratadine HPLC/MS/MS 0,05  
73 Desmethylfluoxetine GC/MS 0,4  
74 Dexamethasone HPLC/MS/MS 0,25  
75 Dexketoprofen HPLC/MS/MS 50  
76 Dextromethorphan HPLC/MS/MS 0,01  
77 Diclofenac HPLC/MS/MS 5  
78 Didanosine HPLC/MS/MS 20  
79 Dienogest HPLC/MS/MS 1  
80 Diosmetin-3-O-glucuronide HPLC/MS/MS 0,05  
81 Donepezil HPLC/MS/MS 0,2  
82 Doxazosin HPLC 0,4  
83 Doxylamine HPLC/MS/MS    
84 Drospirenone HPLC/MS/MS 0,5  
85 Drotaverine HPLC/MS/MS 3  
86 Duloxetine HPLC/MS/MS 0,5  
87 Dutasteride HPLC/MS/MS 0,05  
88 Emoxipine HPLC/MS/MS 5  
89 Enalapril HPLC/MS/MS 1  
90 Enalaprilat HPLC/MS/MS 1,2  
91 Entecavir HPLC/MS/MS 0,05  
92 Eplerenon HPLC/MS/MS 10  
93 Epoxycarbamazepin HPLC 25  
94 Erlotinib HPLC/MS/MS 5  
95 Escitalopram HPLC/MS/MS 0,25  
96 Esomeprazole HPLC/MS/MS 10  
97 Estradiol HPLC/MS/MS 0,0008 determination of endogenous levels in postmenopausal women
98 Estrone HPLC/MS/MS 0,001 determination of endogenous levels in postmenopausal women
99 Estrone sulfate HPLC/MS/MS 0,01 determination of endogenous levels in postmenopausal women
100 Eszopiclon HPLC/MS/MS 0,25  
101 Ethinylestradiol HPLC/MS/MS 0,001  
102 Ethylmethylhydroxypyridine HPLC/MS/MS 0,25  
103 Ethylmethylhydroxypyridine HPLC/MS/MS 1  
104 Etoricoxib HPLC/MS/MS 5  
105 Everolimus HPLC/MS/MS 1 in whole blood
106 Exemestane HPLC/MS/MS 0,25  
107 Ezetimibe HPLC/MS/MS 0,04 common method with ezetimibe glucuronide
108 Ezetimibe HPLC/MS/MS 0,08 common method with atorvastatin
109 Ezetimibe HPLC/MS/MS 0,05 common method with simvastatin
110 Ezetimibe HPLC/MS/MS 0,05 common method with atorvastatin and ezetimibe glucuronide
111 Ezetimibe glucuronide HPLC/MS/MS 1 common method with atorvastarin and ezetimibe
112 Ezetimibe glucuronide HPLC/MS/MS 0,8 common method with ezetimibe
113 Ezetimibe glucuronide HPLC/MS/MS 0,8 common method with atorvastatin
114 Famotidine HPLC 2,5  
115 Fenpiverinium HPLC/MS/MS 0,03 common method with ketorolac and pitofenone
116 Fenspiride HPLC/MS/MS 1  
117 Fenspiride HPLC/MS/MS 1  
118 Fingolimod HPLC/MS/MS 0,01 in whole blood
119 Fluoxetine GC/MS 0,4  
120 Flupirtine HPLC/MS/MS 20  
121 Flupirtine HPLC/MS/MS 10  
122 Flurbiprofen HPLC/MS/MS 100  
123 Fluvoxamine HPLC 1,5  
124 Fosfomycin HPLC/MS/MS 500  
125 Fulvestrant HPLC/MS/MS 0,2  
126 Furagin (Furazidine) HPLC/MS/MS 2  
127 Furagin (Furazidine) HPLC/MS/MS 100  
128 Ganciclovir HPLC/MS/MS 50  
129 Gentamicin HPLC/MS/MS   in animals samples
130 Glargine ELISA 7,5 µU/mL  
131 Gliclazide HPLC/MS/MS 20  
132 Glimepiride HPLC/MS/MS 1  
133 Glucosamine HPLC/MS/MS 10  
134 Glycoursodeoxycholic acid HPLC/MS/MS 20 endogenous compound
135 Hydrochlorothiazide HPLC/MS/MS 0,2  
136 Hydrochlorothiazide HPLC/MS/MS 0,5  
137 Hydrocortisone HPLC/MS/MS 10 endogenous compound
138 Hydroxyurea HPLC/MS/MS 250  
139 Ibuprofen HPLC/MS/MS 500  
140 Ibuprofen HPLC/MS/MS 250  
141 Isoprinosine (DIP) HPLC/MS/MS 10  
142 Isoprinosine (PAcBA) HPLC/MS/MS 50  
143 Imatinib HPLC/MS/MS 20  
144 Indapamide HPLC/MS/MS 1 in whole blood
145 Insulin ELISA 6,25 µU/mL  
146 Insulin ELISA 12,5 µU/mL  
147 Insulin ELISA 4 µU/mL  
148 Ipidacrine HPLC/MS/MS 0,1  
149 Irbesartan HPLC/MS/MS 5  
150 Isoprinosine (DIP) HPLC/MS/MS 80  
151 Isoprinosine (PAcBA) HPLC/MS/MS 200  
152 Ivabradine HPLC/MS/MS 0,25  
153 Ketorolac HPLC/MS/MS 3 common method with fenpiverinium and pitofenone
154 Ketorolac HPLC/MS/MS 30  
155 Lacidipine HPLC/MS/MS 0,02  
156 Lenalidomide HPLC/MS/MS 2  
157 Letrozole HPLC/MS/MS 0,5  
158 Letrozole HPLC/MS/MS 1  
159 Levetiracetam HPLC/MS/MS 200  
160 Levocetirizine HPLC/MS/MS 2,5  
161 Levocetirizine HPLC/MS/MS 1 common method with montelucast
162 Levofloxacine HPLC/MS/MS 100  
163 Levothyroxine HPLC/MS/MS 10 endogenous compound
164 Linagliptin HPLC/MS/MS 0,1 common method with dapagliflozin
165 Linezolid HPLC/MS/MS 200  
166 Liothyronine HPLC/MS/MS 0,25 endogenous compound
167 Lisinopril HPLC/MS/MS 1  
168 Lornoxicam HPLC/MS/MS 20  
169 Losartan HPLC/MS/MS 3  
170 Lovastatin GC/MS/MS 0,15  
171 Lovastatin hydroxyacid GC/MS/MS 0,15  
172 Mebeverine acid HPLC/MS/MS 10  
173 Mebeverine acid, desmethyl HPLC/MS/MS 10  
174 Megestrol acetate HPLC/MS/MS 1  
175 Meldonium HPLC/MS/MS 100  
176 Meloxicam HPLC 30  
177 Meloxicam HPLC/MS/MS 20  
178 Memantine HPLC/MS/MS 0,2  
179 Metformin HPLC/MS/MS 10  
180 Methyldopa HPLC/MS/MS 20  
181 Methylsulfoxyethanol (MSE) HPLC/MS/MS 200  
182 Metoprolol HPLC/MS/MS 1  
183 Metronidazole HPLC/MS/MS 20  
184 Mianserin chiral HPLC/MS/MS 0,2  
185 Micophenolic acid HPLC/MS/MS 500  
186 Mildronate HPLC/MS/MS 50  
187 Milnacipran HPLC/MS/MS 2  
188 Misoprostol acid HPLC/MS/MS 0,05  
189 Misoprostol acid HPLC/MS/MS 0,025  
190 Moclobemide HPLC 30  
191 Montelukast HPLC/MS/MS 1  
192 Montelukast HPLC/MS/MS 2 common method with levocetirizine
193 Moxifloxacin HPLC/MS/MS 50  
194 Moxonidine HPLC/MS/MS 0,02  
195 N,N-Didesmethyl Sibutramine HPLC/MS/MS 0,1 common method with N-desmethyl sibutramine and sibutramine
196 N-Desmethyl Sibutramine HPLC/MS/MS 0,1 common method with N,N-Didesmethyl sibutramine and sibutramine
197 Naftidrofuryl HPLC 200  
198 Naproxen HPLC/MS/MS 200  
199 Naproxen HPLC/MS/MS 10 in urine
200 Naproxen HPLC/MS/MS 500  
201 Nebivolol HPLC/MS/MS 0,02  
202 Nerofe HPLC/MS/MS 1 000,00 in dog plasma
203 Nevirapine HPLC/MS/MS 25  
204 Nitrofurantoin HPLC/MS/MS 2  
205 Norgestimate HPLC/MS/MS 0,0004  
206 O-desmethyltramadol HPLC/MS/MS 0,5  
207 O-desmethylvenlafaxine HPLC/MS/MS 0,5  
208 O-hydroxy atorvastatin HPLC/MS/MS 0,4 common method with ezetimibe
209 Olanzapine HPLC/MS/MS 0,1  
210 Olanzapine HPLC/MS/MS 0,25  
211 Olmesartan HPLC/MS/MS 10  
212 Omeprazole HPLC/MS/MS 10  
213 Ondansetron HPLC/MS/MS 1  
214 Oracin HPLC 20  
215 Ornidazole HPLC/MS/MS 200  
216 Oseltamivir HPLC/MS/MS 0,5  
217 Oxybutynin GC/MS 0,2  
218 Paliperidon HPLC/MS/MS 0,2  
219 Paraxantine HPLC/MS/MS 100 common method with caffeine
220 Paroxetine HPLC/MS/MS 0,1  
221 Paroxetine HPLC/MS/MS 0,025  
222 Paroxetine metabolite HPLC/MS/MS 0,2  
223 Pentoxifylline HPLC/MS/MS 1  
224 Pentoxifylline metabolite M1 HPLC/MS/MS 2  
225 Pentoxifylline metabolite M5 HPLC/MS/MS 10  
226 Perindopril HPLC/MS/MS 2,5  
227 Perindoprilate HPLC/MS/MS 0,25  
228 p-hydroxy atorvastatin HPLC/MS/MS 0,04 common method with ezetimibe
229 Pioglitazone HPLC/MS/MS 10  
230 Pioglitazone metabolite M IV HPLC/MS/MS 5  
231 Piracetam HPLC/MS/MS 500  
232 Pitofenone HPLC/MS/MS 1 common method with ketorolac and fenpiverinium
233 Pizotifen GC/MS/MS 0,05  
234 Pramipexole HPLC/MS/MS 0,02  
235 Pramipexole HPLC/MS/MS 0,01  
236 Prednisolone HPLC/MS/MS 3  
237 Pregabalin HPLC/MS/MS 50  
238 Pridinol HPLC/MS/MS 0,2  
239 Pridinol HPLC/MS/MS 1 in urine
240 Propafenone HPLC/MS/MS 1  
241 Propiverine HPLC/MS/MS 0,5  
242 Quetiapine HPLC/MS/MS 1  
243 Raloxifene HPLC/MS/MS 0,01  
244 Raloxifene-4-glucoronide HPLC/MS/MS 1  
245 Raloxifene-6-glucoronide HPLC/MS/MS 0,5  
246 Ramipril HPLC/MS/MS 0,2  
247 Ramipril HPLC/MS/MS 0,4  
248 Ramipril HPLC/MS/MS 0,05 in dog plasma
249 Ramiprilate HPLC/MS/MS 0,2  
250 Ramiprilate HPLC/MS/MS 0,5 in dog plasma
251 Ranitidin HPLC 10  
252 Ranolazine HPLC/MS/MS 25  
253 Rasagiline HPLC/MS/MS 0,1  
254 Rebamipide HPLC/MS/MS 4  
255 Ribavirin HPLC/MS/MS 3  
256 Risperidone HPLC/MS/MS 0,1  
257 Ritonavir HPLC/MS/MS 20  
258 Rizatriptan HPLC/MS/MS 0,1  
259 Ropinirole HPLC/MS/MS 0,1  
260 Rosuvastatin HPLC/MS/MS 0,05  
261 Salicylic acid HPLC 200  
262 Salicylic acid HPLC/MS/MS 100 common method with acetylsalicylic acid
263 Salicylic acid HPLC/MS/MS 20 common method with acetylsalicylic acid
264 Sibutramine HPLC/MS/MS 0,1 common method with N,N-didesmethyl sibutramine and N-desmethyl sibutramine
265 Sildenafil HPLC/MS/MS 1  
266 Sildenafil HPLC/MS/MS 5  
267 Simvastatin GC/MS/MS 0,5  
268 Simvastatin LC/MS/MS 0,5  
269 Simvastatin LC/MS/MS 0,2 common method with ezetimibe
270 Simvastatin LC/MS/MS 0,2  
271 Simvastatin hydroxyacid GC/MS/MS 0,1  
272 Simvastatin hydroxyacid LC/MS/MS 0,1  
273 Simvastatin hydroxyacid LC/MS/MS 0,05 common method with ezetimibe
274 Sitagliptin HPLC/MS/MS 1  
275 Solifenacin HPLC/MS/MS 0,2  
276 Tadalafil HPLC/MS/MS 5  
277 Tamsulosin HPLC/MS/MS 0,2  
278 Tamsulosin HPLC/MS/MS 0,1  
279 Tamsulosin HPLC/MS/MS 0,05  
280 Tauroursodeoxycholic acid HPLC/MS/MS 5 endogenous compound
281 Telmisartan HPLC/MS/MS 2  
282 Tenofovir HPLC/MS/MS 5  
283 Terbinafine HPLC 20  
284 Thiocolchicoside metabolite M1 HPLC/MS/MS 1  
285 Tianeptine chiral HPLC/MS/MS 2  
286 Ticagrelor HPLC/MS/MS 5  
287 Tiotropium HPLC/MS/MS 0,0001  
288 Tolperisone HPLC/MS/MS 0,5  
289 Tolterodine HPLC/MS/MS 0,05  
290 Torasemide HPLC/MS/MS 20  
291 Toremifene HPLC/MS/MS 2  
292 Tramadol GC/MS 6  
293 Tramadol HPLC/MS/MS 5  
294 Trimetazidine HPLC/MS/MS 0,5  
295 Ulipristal HPLC/MS/MS 0,2  
296 Uridine HPLC/MS/MS 150 endogenous compound
297 Ursodeoxycholic acid HPLC/MS/MS 10 endogenous compound
298 Valganciclovir HPLC/MS/MS 5  
299 Valproic acid HPLC/MS/MS 250  
300 Valsartan HPLC/MS/MS 50  
301 Vardenafil HPLC/MS/MS 0,25  
302 Venlafaxine HPLC/MS/MS 10 in rat plasma
303 Venlafaxine HPLC/MS/MS 0,5  
304 Vildagliptin HPLC/MS/MS 2  
305 Voriconazole HPLC/MS/MS 5  
306 Warfarin HPLC 20  
307 Zidovudine HPLC/MS/MS 25  
308 Zolpidem HPLC 1 plasma direct injection
309 Zopiclon HPLC 4  
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